Подавление ионизации как частный случай матричных эффектов в жидкостной хроматографии-масс-спектрометрии (обобщающая статья)

Метод высокоэффективной жидкостной хроматографии-масс-спектрометрии (ВЭЖХ-МС) с ионизацией при атмосферном давлении является одним из наиболее селективных и чувствительных, при этом он, как и другие аналитические методы, подвержен матричным эффектам. Одним из наименее изученных и наиболее непредсказуемым проявлением матричных эффектов при ВЭЖХ-МС анализе является подавление ионизации аналита компонентами матрицы (ion suppression). Поскольку данное явление может оказывать значительное влияние на такие параметры метода, как предел обнаружения, предел определения, точность и воспроизводимость, очевидно, что оценка вклада данного вида матричных эффектов и его учет при количественном анализе необходимы в процессе разработки и валидации методик. В статье обсуждены возможные причины и механизмы возникновения подавления ионизации, приведена максимально сжатая информация об основных подходах к выявлению этого эффекта, путях его минимизации и способах учета при измерениях.

high performance liquid chromatography-mass spectrometry (HPLC-MS), matrix effects, suppression of ionization, ionization enhancement, высокоэффективная жидкостная хроматография-масс-спектрометрия (ВЭЖХ-МС), матричные эффекты, подавление ионизации (ion supression), усиление ионизации

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